Findings in a mouse model of multiple sclerosis highlight the contribution of CD8+ T cells, previously largely ignored in this disease. The work also helps answer why certain variants of the human leukocyte antigen (HLA) complex are protective, while others increase risk for disease (pages 1227–1235).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sospedra, M. & Martin, R. Annu. Rev. Immunol. 23, 683–747 (2005).
Friese et al. Nat. Med. 14, 1227–1235 (2008).
Babbe, H. et al. J. Exp. Med. 192, 393–404 (2000).
Huseby, E.S. et al. J. Exp. Med. 194, 669–676 (2001).
Fogdell-Hahn, A., Ligers, A., Gronning, M., Hillert, J. & Olerup, O. Tissue Antigens 55, 140–148 (2000).
Harbo, H.F. et al. Tissue Antigens 63, 237–247 (2004).
Brynedal, B. et al. PLoS ONE 2, e664 (2007).
Bertrams, H.J. & Kuwert, E.K. J. Immunol. 117, 1906–1912 (1976).
Vogt, A.B. et al. J. Immunol. 153, 1665–1673 (1994).
Klein, L., Klugmann, M., Nave, K.A., Tuohy, V.K. & Kyewski, B. Nat. Med. 6, 56–61 (2000).
Honma, K. et al. J. Neuroimmunol. 73, 7–14 (1997).
McRae, B.L., Vanderlugt, C.L., Dal Canto, M.C. & Miller, S.D. J. Exp. Med. 182, 75–85 (1995).
Gregersen, J.W. et al. Nature 443, 574–577 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Martin, R. HLA class I: friend and foe of multiple sclerosis. Nat Med 14, 1150–1151 (2008). https://doi.org/10.1038/nm1108-1150
Issue Date:
DOI: https://doi.org/10.1038/nm1108-1150
