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A deer in the headlights: BAMBI meets liver fibrosis

Lipopolysaccharide signaling through the Toll-like receptors downregulates an inhibitory pseudoreceptor of TGF-β, enhancing hepatic fibrosis and liver injury (pages 1324–1332).

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Figure 1: Fibrogenic signaling induced by TLR4 in hepatic stellate cells and the role of Kupffer cells.

Kim Caesar

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Friedman, S. A deer in the headlights: BAMBI meets liver fibrosis. Nat Med 13, 1281–1282 (2007). https://doi.org/10.1038/nm1107-1281

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