In several neurodegenerative disorders, including Parkinson disease, specific neurons are vulnerable to death whereas others are spared. It now appears that the neurotransmitter dopamine may damage parkin, a neuroprotective protein, in susceptible neurons and contribute to their demise (pages 1214–1221).
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Katie Ris
References
Braak, H. et al. Neurobiol. Aging 24, 197–211 (2003).
La Voie, M. et al. Nat. Med. 11, 1214–1221 (2005).
Cookson, M.R. Annu. Rev. Biochem 74, 29–52 (2005).
Feany, M.B. & Pallanck, L.J. Neuron 38, 13–16 (2003).
Imai, Y. et al. Cell 105, 891–902 (2001).
Petrucelli, L. et al. Neuron 36, 1007–1019 (2002).
Darios, F. et al. Hum. Mol. Genet. 12, 517–526 (2003).
Lo Bianco, C. et al. Proc. Natl. Acad. Sci. USA 101, 17510–17515 (2004).
Winklhofer, K.F. et al. J. Biol. Chem. 278, 47199–47208 (2003).
Chung, K.K. et al. Science. 304, 1328–1331 (2004).
Yao, D. et al. Proc. Natl. Acad. Sci. 101, 10810–10814 (2004).
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Cookson, M. Neurons inflict self-harm. Nat Med 11, 1159–1161 (2005). https://doi.org/10.1038/nm1105-1159
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DOI: https://doi.org/10.1038/nm1105-1159
