The finding that CD38 mediates a sustained calcium signal inside neutrophils, which directs their movement toward lung tissue infected with pneumococcus bacteria suggests a new mechanism by which the immune system prevents the spread of bacterial infection. (pages 1209–1216)
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References
Tomasz A Antibiotic resistance in Streptococcus pneumoniae. Clin. Infect. Dis. 24, 85–88 (1997).
Örtqvist, A. et al. Aetiology, outcome and prognostic factors in community-acquired pneumonia requiring hospitalisation. Eur. Respir. J. 3, 1105–1113 (1990).
Partida-Sanchéz, S. et al. Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo. Nature Med. 7, 1209–1216 (2001).
Gao, J.-L., Lee, E.J. & Murphy, P.M. Impaired antibacterial host defence in mice lacking the N-formylpeptide receptor. J. Exp. Med . 189, 657–662 (1999).
Streb, H., Irvine, R.F., Berridge, M.J. & Schulz, I. Release of Ca++ from a non-mitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-triphosphate. Nature 306, 67–68 (1983).
Clapper DL, Walseth TF, Dargie PJ, Lee HC . Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol triphosphate. J. Biol. Chem. 262, 9561–9568 (1987).
Galione, A., Lee, H.C. & Busa, W.B. Ca++-induced Ca++ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose. Science 253, 1143–1146 (1991).
Howard, M. et al. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 262, 1056–1059 (1993).
Guse, A.H. et al. Regulation of Ca++-signaling in T-lymphocytes by the second messenger cyclic ADP-ribose. Nature 398, 70–73 (1999).
Novak, R., Henriques, B., Charpentier, E., Normark, S. & Tuomanen, E. Emergence of vancomycin tolerance in Streptococcus pneumoniae. Nature 399, 590–593 (1999).
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Normark, S., Henriques Normark, B. & Hornef, M. How neutrophils recognize bacteria and move toward infection. Nat Med 7, 1182–1184 (2001). https://doi.org/10.1038/nm1101-1182
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DOI: https://doi.org/10.1038/nm1101-1182
