Understanding the cell cycle

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Changes in maturation-promoting factor (MPF) and cytostatic factor (CSF) activities during meiotic divisions of oocytes and mitotic divisions of early zygotes.
Figure 2: The pattern of the progress in understanding cell division.

References

  1. 1

    Gurdon, J.B. and Woodland, H.R. The cytoplasmic control of nuclear activities in animal development. Biol. Rev. 43, 233–267 (1968).

    CAS  Article  Google Scholar 

  2. 2

    Hartwell, H. L., Culotti, J. & Reid, B. Genetic control of the cell-division cycle in yeast. I Detection of mutants. Proc. Natl. Acad. Sci. USA 66 , 352–359 (1970).

    CAS  Article  Google Scholar 

  3. 3

    Masui, Y. & Markert, C.L. Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes. J. Exp. Zool. 177, 129–145 ( 1971).

    CAS  Article  Google Scholar 

  4. 4

    Wasserman, W.J. & Masui, Y. A cytoplasmic factor promoting oocyte maturation: its extraction and preliminary characterization . Science 199, 1266–1268 (1976).

    Article  Google Scholar 

  5. 5

    Kishimoto, T. & Kanatani, H. Cytoplasmic factor responsible for germinal vesicle breakdown and meiotic maturation in starfish oocytes . Nature 221, 273–274 (1976).

    Google Scholar 

  6. 6

    Wasserman, W.J. & Smith, L.D. The cyclic behavior of a cytoplasmic factor controlling nuclear membrane breakdown. J. Cell Biol. 78, R12–R22 (1978).

    Article  Google Scholar 

  7. 7

    Sunkara, P.S., Wright, D. & Rao, P.N. Mitotic factors from mammalian cells induce germinal vesicle breakdown and chromosome condensation in amphibian oocytes. Proc. Natl. Acad. Sci. USA 76, 2799–2802 (1979).

    CAS  Article  Google Scholar 

  8. 8

    Weintraub, H. et al. Mise en évidence d'une activité "MPF" chez les Sccharomyces cerevisae. C. R. Acad. Sci. Paris Ser. III 295, 787–790 (1982).

    CAS  Google Scholar 

  9. 9

    Evans, R., Rosenthal, E.T., Youngblom, J., Distel, D. & Hunt, T. Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 33, 389–396 ( 1983).

    CAS  Article  Google Scholar 

  10. 10

    Simanis, V. & Nurse, P. The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation. Cell 45, 261 –268 (1986).

    CAS  Article  Google Scholar 

  11. 11

    Swenson, K.I., Farrell, K.M. & Ruderman, J.V. The clam embryo protein cyclin A induces entry into M-phase and the resumption of meiosis in Xenopus oocytes. Cell 47, 861–870 ( 1986).

    CAS  Article  Google Scholar 

  12. 12

    Lohka, M.J., Hayes, M.K. & Maller, J.L. Purification of maturation-promoting factor, an intracellular regulator of early mitotic events. Proc. Natl. Acad. Sci. USA 85, 3009–3013 (1988).

    CAS  Article  Google Scholar 

  13. 13

    Labbé, J.C. et al. MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B. EMBO J. 8, 3053–3058 ( 1989).

    Article  Google Scholar 

  14. 14

    Tyson, J.J., Novak, B., Odell, G. M., Chen, K. & Thron, C.D. Chemical kinetic theory as a tool for understanding the regulation of M-phase promoting factor in the cell cycle. Trends Biochem. Sci. 21, 89–96 (1996).

    CAS  Article  Google Scholar 

  15. 15

    Wood, W. B. & Edgar, R. S. Building a Bacterial Virus. Sci. Am. 217, 61–66 ( 1967).

    CAS  Article  Google Scholar 

  16. 16

    Hartwell, L. H., Culotti, J., Pringle, J.R. & Reid, B.J. Genetic control of the cell division cycle in yeast. Science 183, 46-51 (1974).

    CAS  Article  Google Scholar 

  17. 17

    Nurse, P., Thuriaux, P. & Nasmyth, K. Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet. 146 , 167–178 (1976).

    CAS  Article  Google Scholar 

  18. 18

    Hara, K., Tydeman, P. & Kirschner, M. 1980. A cytoplasmic clock with the same period as the division cycle in Xenopus eggs. Proc. Natl. Acad. Sci. USA 77, 462–466 (1980).

    CAS  Article  Google Scholar 

  19. 19

    Nurse, P. Universal control mechanism regulating onset of M-phase. Nature 344, 503–508 ( 1990).

    CAS  Article  Google Scholar 

  20. 20

    Murray, A. & Hunt, T. in The Cell Cycle (W. H. Freeman and Company, New York, 1993).

    Google Scholar 

  21. 21

    Hartwell, L. H. & Weinert, T.A. Checkpoints: Controls that ensure the order of cell cycle events. Science 246, 629–634 (1989).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nurse, P., Masui, Y. & Hartwell, L. Understanding the cell cycle. Nat Med 4, 1103–1106 (1998). https://doi.org/10.1038/2594

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing