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Zinc fingers hit off target

Nature Medicine volume 17, pages 11921193 (2011) | Download Citation

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References

  1. 1.

    , , & Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nat. Meth. 8, 765–770 (2011).

  2. 2.

    et al. An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat. Biotechnol. 29, 816–823 (2011).

  3. 3.

    et al. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat. Biotechnol. 27, 851–857 (2009).

  4. 4.

    et al. Oxidase deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease mediated safe harbor targeting. Blood 117, 5561–5572 (2011).

  5. 5.

    ENCODE Project Consortium et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447, 799–816 (2007).

  6. 6.

    et al. In vivo genome editing restores haemostasis in a mouse model of haemophilia. Nature 475, 217–221 (2011).

  7. 7.

    & Chimeric nucleases stimulate gene targeting in human cells. Science 300, 763 (2003).

  8. 8.

    , , & Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels. PLoS Genet. 5, e1000376 (2009).

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https://doi.org/10.1038/nm1011-1192

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