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Attacking cancer at its foundation

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Figure 1: Diagram of the translocation that creates the Philadelphia chromosome.
Figure 2: Status of the protein kinase family in the mid-1980s, when the kinase program at Ciba-Geigy began.
Figure 3: Lead optimization.
Figure 4: Imatinib bound to the inactive, closed confirmation of ABL.
Figure 5: Kinase dendrogram interaction maps for imatinib, dasatinib and sunitinib.
Figure 6: Characterization and annotation of compound libraries.

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Acknowledgements

I am grateful to the many people who have participated in the imatanib project, including my former laboratory staff and research and development colleagues at Ciba-Geigy (Novartis), and the many clinical scientists involved in the imatinib clinical program. I would like to acknowledge the major contributions made by E. Buchdunger, B. Druker, H. Mett, P. Traxler and J. Zimmermann. I would also like to acknowledge the support and mentoring of A. Matter and G. Haas during my time at Ciba-Geigy and T. Roberts and B. Hemmings for their support and scientific advice. I would like to thank P. Zarrinker for providing Figures 5 and 6.

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Correspondence to Nicholas Lydon.

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N.L. is a Science Advisory Board member for Ambit Biosciences, and he is an owner of stock in Ambit.

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Lydon, N. Attacking cancer at its foundation. Nat Med 15, 1153–1157 (2009). https://doi.org/10.1038/nm1009-1153

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