Smoke is a solid. Whether from cigarettes, cooking fires or other sources, it is comprised of tiny particles that injure the lung and can lead to lung cancer and chronic obstructive pulmonary disorder, characterized by laborious breathing. Steven D. Shapiro and his colleagues take a look at imaging data in people suggesting that these two conditions have more in common mechanistically than was previously thought. Both diseases seem to stem in part from the ability of inhaled particles to trigger inflammation, a process examined by Robert M. Senior and his colleagues.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Functional analysis of the impact of ORMDL3 expression on inflammation and activation of the unfolded protein response in human airway epithelial cells
Allergy, Asthma & Clinical Immunology Open Access 01 February 2013
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Celli, B.R. et al. Eur. Respir. J. 23, 932–946 (2004).
Dostert, C. et al. Science 320, 674–677 (2008).
Kelsen, S.G. et al. Am. J. Respir. Cell Mol. Biol. 38, 541–550 (2008).
Hornung, V. et al. Nat. Immunol. 9, 847–856 (2008).
Jung, E.J., Avliyakulov, N.K., Boontheung, P., Loo, J.A. & Nel, A.E. Proteomics 7, 3906–3918 (2007).
Hackett, N.R. et al. Am. J. Respir. Cell Mol. Biol. 29, 331–343 (2003).
Adair-Kirk, T.L. et al. Am. J. Respir. Cell Mol. Biol. 39, 400–411 (2008).
Woodruff, P.G. et al. Am. J. Respir. Crit. Care Med. 172, 1383–1392 (2005).
Heguy, A. et al. J. Mol. Med. 84, 318–328 (2006).
Sin, D.D. et al. Am. J. Respir. Crit. Care Med. 177, 1207–1214 (2008).
Bernard, A.M., Roels, H.A., Buchet, J.P. & Lauwerys, R.R. Environ. Res. 66, 96–104 (1994).
Chen, J. et al. Cancer Epidemiol. Biomarkers Prev. 16, 577–583 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Adair-Kirk, T., Atkinson, J. & Senior, R. Smoke particulates stress lung cells. Nat Med 14, 1024–1025 (2008). https://doi.org/10.1038/nm1008-1024
Issue Date:
DOI: https://doi.org/10.1038/nm1008-1024
This article is cited by
-
Decreased proteasomal function accelerates cigarette smoke-induced pulmonary emphysema in mice
Laboratory Investigation (2015)
-
Functional analysis of the impact of ORMDL3 expression on inflammation and activation of the unfolded protein response in human airway epithelial cells
Allergy, Asthma & Clinical Immunology (2013)
-
Genetic association analysis of TAP1 and TAP2 polymorphisms with aspirin exacerbated respiratory disease and its FEV1 decline
Journal of Human Genetics (2011)
-
Extractable organic matter of Standard Reference Material 1649a influences immunological response induced by pathogen-associated molecular patterns
Environmental Science and Pollution Research (2010)