Thickening of the cardiac valves leads to congestive heart failure, chest pain, sudden loss of consciousness and often death. Experiments in mice now link this condition to dysregulation of an endogenous inhibitor of angiogenesis (1151–1159).
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Kalluri, R., Zeisberg, E. Controlling angiogenesis in heart valves. Nat Med 12, 1118–1119 (2006). https://doi.org/10.1038/nm1006-1118
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DOI: https://doi.org/10.1038/nm1006-1118