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β-receptor polymorphisms: heart failure's crystal ball

Nature Medicine volume 9, pages 1260–1262 (2003)Cite this article

An Erratum to this article was published on 01 November 2003

A polymorphism present in about half the general population can predispose to heart failure as well as enhance responsiveness to β-blockers. The mechanism for this is now being revealed (pages 1300–1305).

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Figure 1: Differential β1-adrenergic receptor (β1-AR) signaling and age-dependent, chronic adaptations caused by a polymorphism at amino acid 389.

Renee Lucas

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  1. Halsted 500, Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Baltimore, 21287, Maryland, USA

    David A Kass

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Kass, D. β-receptor polymorphisms: heart failure's crystal ball. Nat Med 9, 1260–1262 (2003). https://doi.org/10.1038/nm1003-1260

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