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The new immunosuppression: just kill the T cell

Nature Medicine volume 9, pages 1259–1260 (2003)Cite this article

Antibodies to the CD40 ligand have modulated the immune system in animal experiments and in human clinical trials. Assumptions about how these antibodies work are now reexamined (pages 1275–1280).

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Figure 1: CD40L and tolerance: proposed mechanism by which CD40L antibody therapy induces dominant tolerance when associated with transplanted tissue grafts, and deletional tolerance when combined with substantial infusions of donor bone marrow cells.

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  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    Herman Waldmann

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  1. Herman Waldmann
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Waldmann, H. The new immunosuppression: just kill the T cell. Nat Med 9, 1259–1260 (2003). https://doi.org/10.1038/nm1003-1259

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