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Plugging the leaks

Nature Medicine volume 7, pages 1105–1106 (2001)Cite this article

It has been known for over 20 years that vascular leakage in inflammation is dependent on neutrophils. The identification of the permeability-enhancing activity produced by neutrophils provides clues to the development of anti-inflammatory drugs with a new mechanism of action (pages 1123–1127).

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Figure 1: At a site of inflammation, a neutrophil is activated by a chemoattractant (yellow circle), and adheres to an endothelial cell through β2 integrins (green heterodimers on neutrophil surface; for example, leukocyte function associated molecule-1 (LFA-1)) becoming engaged to endothelial ligands such as intracellular adhesion molecule-1 (ICAM-1).

Bob Crimi

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  1. Department of Biomedical Engineering and Cardiovascular Research Center University of Virginia Health Sciences Center, Charlottesville, Virginia, USA

    Klaus Ley

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  1. Klaus Ley
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Ley, K. Plugging the leaks. Nat Med 7, 1105–1106 (2001). https://doi.org/10.1038/nm1001-1105

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