Several knockout mouse models of leanness and obesity resistance have been reported over the past several years and have advanced our understanding of the pathogenesis and treatment of obesity. A new lean mouse model has been generated by inactivating the gene for an inhibitor of mRNA translation. (pages 1128–1131)
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Chen, H., Farese, R. Turning WAT into BAT gets rid of fat. Nat Med 7, 1102–1103 (2001). https://doi.org/10.1038/nm1001-1102
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DOI: https://doi.org/10.1038/nm1001-1102
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