Predicting how proteins fold from their amino acid sequence is largely a matter of guesswork. But the rules may be written into the genetic code (pages 894–901).
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Blalock, J. Genetic origins of protein shape and interaction rules. Nat Med 1, 876–878 (1995). https://doi.org/10.1038/nm0995-876
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DOI: https://doi.org/10.1038/nm0995-876
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