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Schizophrenia drug says goodbye to dopamine

A drug that activates glutamate receptors offers promise for a new class of anti-psychotic therapeutics and sheds light on the pathophysiology of this devastating disease (pages 1102–1107).

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Figure 1: The novel compound for treating schizophrenia described in the study by Patil et al. is a specific agonist of the so-called group II metabotropic glutamate receptors, mGlurR2 and mGluR3.

Katie Ris-Vicari

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Weinberger, D. Schizophrenia drug says goodbye to dopamine. Nat Med 13, 1018–1019 (2007). https://doi.org/10.1038/nm0907-1018

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