Ligands from commensal microflora can stimulate Toll-like receptors on the surface of intestinal epithelial cells. Work in mice now assigns a surprising role to such signals: cell survival and repair during inflammation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Akira, S. & Takeda, K. Nat. Rev. Immunol. 4, 499–511 (2004).
Backhed, F. & Hornef, M. Microbes Infect. 5, 951–959 (2003).
Otte, J., Cario, E. & Podolsky, D.K. Gastroenterology 126, 1054–1070 (2004).
Rackoff-Nahoum, S. et al. Cell 118, 229–241 (2004).
Hooper, L.V. & Gordon, J.I. Science 292, 1115–1118 (2001).
Abreu, M.T. et al. J. Endotoxin Res. 9, 322–330 (2003).
Macpherson, A.J. & Uhr, T. Science 303, 1662–1665 (2004).
Kobayashi, M. et al. J. Clin. Invest. 111, 1297–1308 (2003).
Bouma, G., Kaushiva, A. & Strober, W. Gastroenterology 123, 554–565 (2002).
Strober, W., Fuss, I.J. & Blumberg, R.S. Annu. Rev. Immunol. 20, 495–549 (2002).
Rachmilewitz, D. et al. Gastroenterology 122, 1428–1441 (2002).
Rachmilewitz, D., Katakura, K. & Karmeli, F. Gastroenterology 126, 520–528 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Strober, W. Epithelial cells pay a Toll for protection. Nat Med 10, 898–900 (2004). https://doi.org/10.1038/nm0904-898
Issue Date:
DOI: https://doi.org/10.1038/nm0904-898
This article is cited by
-
The Skin Microbiome in Atopic Dermatitis—a Potential Treatment Target?
Current Dermatology Reports (2018)
-
Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota
Journal of Microbiology (2016)
-
The skin microbiome
Nature Reviews Microbiology (2011)
-
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Nature (2008)
-
Role of MyD88 in TLR agonist-induced functional alterations of human adipose tissue-derived mesenchymal stem cells
Molecular and Cellular Biochemistry (2008)