Re-evaluating sarcoplasmic reticulum function in heart failure

Article metrics

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: a, Hematoxylin and eosin-stained histological sections demonstrate dilated cardiomyopathy induced by the tropomodulin transgene (TOT) which is not rescued by phospholamban ablation (PLB).

References

  1. 1

    Ho, K.K., Pinsky, J.L., Kannel, W.B. & Levy, D. The epidemiology of heart failure: the Framingham Study. J. Am. Coll. Cardiol. 22, 6–13 (1993).

  2. 2

    Kiriazis. H. & Kranias, E.G. Genetically engineered models with alterations in cardiac membrane calcium-handling proteins. Annu. Rev. Physiol. 62, 321–351 (2000).

  3. 3

    Minamisawa, S., et al. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell. 99, 313–322 (1999).

  4. 4

    Sussman, M.A., et al. Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile J. Clin. Invest. 101, 51–61 (1998).

  5. 5

    Sussman, M.A., et al. Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice. Am. J. Pathol. 155, 2101–2113 (1999).

  6. 6

    Rockman, H.A., et al. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc. Natl. Acad. Sci. USA. 95, 7000–7005 (1998).

  7. 7

    Chien, K.R. Stress pathways and heart failure. Cell 98, 555–558 (2000).

  8. 8

    Olson, E.N. & Williams, R.S. Calcineurin signaling and muscle remodeling. Cell 101, 689–692 (2000).

  9. 9

    Chien, K.R. Genomic circuits and the integrative biology of complex cardiac diseases. Nature, in press, 2000.

  10. 10

    Huang, WY et al. Transgenic expression of green fluorescence protein can cause dilated cardiomyopathy. Nature Med. 6, 482–483 (2000).

  11. 11

    Chien, K.R. Meeting Koch's postulates for calcium signaling in cardiac hypertrophy. J. Clin. Invest. 105, 1339–1342 (2000).

  12. 12

    Miyamoto, M. E. et al., Adenoviral gene transfer of SERCA2a improves left ventricular function in aortic-banded rats in transition to heart failure. Proc. Natl. Acad. Sci. USA 97, 793–798 (2000).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading