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Evidence of an X-linked or recessive genetic component to prostate cancer risk


We used data from a population-based cohort study of blacks, Hispanics, Japanese and whites to examine the frequency of prevalent prostate and breast cancer by family history status of first-degree relatives (parents and siblings). Independent of race, the age-adjusted relative risk for prevalent prostate cancer in subjects with affected brothers was approximately two times that in subjects with affected fathers (P < 0.00005). No such excess risk for breast cancer was observed among subjects with affected sisters compared to those with affected mothers (age- and race-adjusted relative risk = 1.10, P= 0.34). The magnitude of the relative risk for prostate cancer in sibling-versus parent-affected groups was significantly different from that of the comparable relative risk for breast cancer (P < 0.00005). An excess risk of prostate cancer in men with affected brothers compared to those with affected fathers is consistent with the hypothesis of an X-linked, or recessive, model of inheritance.

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  1. 1

    Narod, S.A. et al. The impact of family history on early detection of prostate cancer. Nature Med. 1, 99–101 (1995).

  2. 2

    Woolf, C.M. An investigation of the familial aspects of carcinoma of the prostate. Cancer 13, 739–744 (1960).

  3. 3

    Cancer in Los Angeles County: A Portrait of Incidence and Mortality 1972–1987 (University of Southern California Press, Los Angeles,1991).

  4. 4

    Hayes, R.B. et al. Prostate cancer risk in U.S. blacks and whites with a family history of cancer. Int. J. Cancer 60, 361–364 (1995).

  5. 5

    Whittemore, A.S. et al. Family history and prostate cancer risk in black, white, and Asian men in the United States and Canada. Am. J. Epidemiol. 141, 732–740 (1995).

  6. 6

    Ross, R.K. et al. Does the racial-ethnic variation in prostate cancer risk have a hormonal basis? Cancer 75, 1778–1782 (1995).

  7. 7

    Edwards, A. et al. Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics 12, 241–253 (1992).

  8. 8

    Coetzee, G. & Ross, R.K. Prostate cancer and the androgen receptor. J. natn. Cancer Inst. 86, 872–873 (1994).

  9. 9

    Irvine, R.A. et al. The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res. 55, 1937–1940 (1995).

  10. 10

    Carter, B.S. et al. Mendelian inheritance of familial prostate cancer. Proc. natn. Acad. Sci. U.S.A. 89, 3367–3371 (1992).

  11. 11

    Breslow, N.E. & Day, N.E. Statistical Methods in Cancer Research, Vol. II, The Design and Analysis of Cohort Studies (IARC Scientific Publications No. 82, International Agency for Research on Cancer, Lyon, 1987).

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