Targeting dendritic cell metabolism in cancer

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Cancers can compromise the capacity of the host immune system to recognize tumor antigens. Recent findings now show that increased accumulation of lipids in dendritic cells in tumors can impair presentation of tumor antigens—which is crucial for activation of the immune system—providing a conceptual framework that may help increase the efficacy of therapeutic vaccines (pages 880–886).

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Figure 1: A new therapeutic strategy targeting lipid metabolism to improve anticancer immune responses.

Katie Vicari

References

  1. 1

    Smyth, M.J., Dunn, G.P. & Schreiber, R.D. Adv. Immunol. 90, 1–50 (2006).

  2. 2

    Zitvogel, L., Tesniere, A. & Kroemer, G. Nat. Rev. Immunol. 6, 715–727 (2006).

  3. 3

    Zitvogel, L. et al. J. Clin. Invest. 118, 1991–2001 (2008).

  4. 4

    Herber, D.L. et al. Nat. Med. 16, 880–886 (2010).

  5. 5

    Steinman, R.M. & Banchereau, J. Nature 449, 419–426 (2007).

  6. 6

    Yi, H. et al. Blood 113, 5819–5828 (2009).

  7. 7

    Beckers, A. et al. Cancer Res. 67, 8180–8187 (2007).

  8. 8

    Menendez, J.A. & Lupu, R. Nat. Rev. Cancer 7, 763–777 (2007).

  9. 9

    Little, J.L., Wheeler, F.B., Fels, D.R., Koumenis, C. & Kridel, S.J. Cancer Res. 67, 1262–1269 (2007).

  10. 10

    Panaretakis, T. et al. Cell Death Differ. 15, 1499–1509 (2008).

  11. 11

    Ramakrishnan, R. et al. J. Clin. Invest. 120, 1111–1124 (2010).

  12. 12

    Zitvogel, L., Apetoh, L., Ghiringhelli, F. & Kroemer, G. Nat. Rev. Immunol. 8, 59–73 (2008).

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Correspondence to Guido Kroemer.

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