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T-ing up inflammation in fat

Obesity generates a proinflammatory environment in adipose tissue, but the factors that initiate this inflammatory cascade have been unclear. Three studies now show that alterations in the composition of adipose tissue T cells occur early in obesity and shape the relationship between immunity and metabolism (pages 914–920, 921–929 and 930–939).

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Figure 1: Alterations in adipose tissue T (ATT) cells with obesity regulate the inflammatory environment in fat.

Katie Vicari

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Correspondence to Alan R. Saltiel.

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Lumeng, C., Maillard, I. & Saltiel, A. T-ing up inflammation in fat. Nat Med 15, 846–847 (2009). https://doi.org/10.1038/nm0809-846

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