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T time in the brain

Nature Medicine volume 15, pages 844–846 (2009)Cite this article

Inflammation in neural tissue has long been suspected to have a role in stroke. A new study in mouse models of focal cerebral ischemia suggest that a stereotyped sequence of T cell infiltration and activation may underlie the progression of brain injury that can last up to days after stroke onset (pages 946–950).

Stroke remains a very challenging clinical problem. In experimental models, cerebral ischemia triggers an elevation in excitotoxic glutamate that rapidly leads to an accumulation of damaging calcium and reactive oxygen species in neurons. However, in spite of remarkable advances in the molecular biology of neuronal cell death, a clinically effective neuroprotectant has not yet been developed. Numerous neuroprotection trials in acute stroke have failed1.

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Figure 1: The sequence of events after cerebral ischemia may comprise multiple phases.

Katie Vicari

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  1. Eng H. Lo is in the Neuroprotection Research Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts, USA.,

    Eng H Lo

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Correspondence to Eng H Lo.

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Lo, E. T time in the brain. Nat Med 15, 844–846 (2009). https://doi.org/10.1038/nm0809-844

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