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Peroxiredoxin-2 links Cdk5 to neurodegeneration

Nature Medicine volume 13, pages 907–909 (2007)Cite this article

Cyclin-dependent kinase 5, a serine/threonine kinase, contributes to neurodegeneration in Parkinson's disease. This kinase is now shown to phosphorylate peroxiredoxin-2, inactivating it, and thereby sensitizing neurons to the deleterious effects of parkinsonian toxins.

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Figure 1: Cyclin-dependent kinase 5 (Cdk5) downregulates peroxiredoxin-2 (Prx2) activity, leading to an accumulation of reactive oxygen species in the MPTP model of Parkinson's disease.

Katie Ris-Vicari

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  1. Serge Przedborski is in the Departments of Neurology, Pathology, and Cell Biology and the Center for Motor Neuron Biology and Disease, Columbia University, New York, New York 10032, USA. sp30@columbia.edu,

    Serge Przedborski

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  1. Serge Przedborski
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Przedborski, S. Peroxiredoxin-2 links Cdk5 to neurodegeneration. Nat Med 13, 907–909 (2007). https://doi.org/10.1038/nm0807-907

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