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Targeted cancer therapeutics: the heartbreak of success

Tyrosine kinase inhibitors, widely hailed for their success as treatments for cancer, are also plagued by the issue of cardiotoxic side effects. The mechanism behind the heart damage now comes to light for one such inhibitor, imatinib mesylate, also known as Gleevec (pages 908916).

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Figure 1: Sustained endoplasmic reticulum stress can lead to apoptosis through several pathways.

Kim Caesar


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Mann, D. Targeted cancer therapeutics: the heartbreak of success. Nat Med 12, 881–882 (2006).

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