News & Views | Published:

Redistricting the retroviral restriction factors

Nature Medicine volume 10, pages 778780 (2004) | Download Citation

Subjects

The cytoplasmic protein TRIM5α blocks the growth of HIV in rhesus monkey cells. Three studies now show that TRIM5α is an even more broadly active inhibitor. It impairs the growth of highly divergent retroviruses in human and other primate cells and fully accounts for many previously described antiretroviral activities.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nature 427, 848–853 (2004).

  2. 2.

    , , , & Proc. Natl. Acad. Sci. USA. Published online 12 July 2004 (doi: 10.1073/pnas.0402361101.)

  3. 3.

    , & Proc. Natl. Acad. Sci. USA. Published online 12 July 2004 (doi: 10.1073/pnas.0402474101.)

  4. 4.

    , , & Proc. Natl. Acad. Sci. USA. Published online 12 July 2004 (doi: 10.1073/pnas.0402876101.)

  5. 5.

    et al. Proc. Natl. Acad. Sci. USA 97, 12295–12299 (2000).

  6. 6.

    et al. J. Virol. 73, 10020–10028 (1999).

  7. 7.

    , , , & J. Virol. 72, 1043–1051 (1998).

  8. 8.

    J. Natl. Cancer Inst. 45, 163–169 (1970).

  9. 9.

    , & J. Virol. 5, 221–225 (1970).

  10. 10.

    & Virology 225, 300–305 (1996).

  11. 11.

    , , & Nature 382, 826–829 (1996).

  12. 12.

    , , & Nature 418, 646–650 (2002).

  13. 13.

    , , & Mol. Cell 12, 591–601 (2003).

  14. 14.

    , , & Nat. Med. 9, 1398–1403 (2003).

  15. 15.

    , & Nat. Med. 9 1404–1407 (2003).

Download references

Author information

Affiliations

  1. Warner C. Greene is at the Gladstone Institute of Virology and Immunology, and University of California, San Francisco, San Francisco, California 94141, USA wgreene@gladstone.ucsf.edu

    • Warner C Greene

Authors

  1. Search for Warner C Greene in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nm0804-778

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing