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Redistricting the retroviral restriction factors

Nature Medicine volume 10, pages 778–780 (2004)Cite this article

The cytoplasmic protein TRIM5α blocks the growth of HIV in rhesus monkey cells. Three studies now show that TRIM5α is an even more broadly active inhibitor. It impairs the growth of highly divergent retroviruses in human and other primate cells and fully accounts for many previously described antiretroviral activities.

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Figure 1: TRIM5α in retroviral restriction.

Erin Boyle

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  1. Gladstone Institute of Virology and Immunology, and University of California, San Francisco, San Francisco, 94141, California, USA

    Warner C Greene

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  1. Warner C Greene
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Greene, W. Redistricting the retroviral restriction factors. Nat Med 10, 778–780 (2004). https://doi.org/10.1038/nm0804-778

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