Expression of a sodium iodide transporter by the thyroid gland causes iodide accumulation, and radioactive iodide is an effective treatment for thyroid cancer. The identification of a similar transporter in mammary tissue indicates that this approach might also be used to treat breast cancer (pages 871–878).
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References
Marine, D. & Feiss, H.O. The absorption of potassium iodide by perfused thyroid glands and some of the factors modifying it. J. Pharmacol. Exp. Ther. 7, 557–576 (1915).
Dai, G., Levy, O. & Carrasco, N. Cloning and characterization of the thyroid iodide transporter . Nature 379, 458–460 (1996).
Tazebay, U.H. et al. The mammary gland iodide transporter is expressed during lactation and in breast cancer. Nature Med. 6, 871 –878 (2000).
Sawin, C.T. & Becker, D.V. Radioiodine and the treatment of hyperthyroidism: the early history. Thyroid 7, 163–176 (1996).
Mandell, R.B., Mandell, L.Z. & Link, C.J. Radioisotope concentrator gene therapy using the sodium/iodide symporter gene. Cancer Res. 59, 661– 668 (1999).
Taurog, A.M. in Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text 8th edn. (eds. Braverman, L.E. & Utiger, R.D.) 61– 85 (Lippincott, Williams & Wilkins, Philadelphia, 2000).
Maxon, H.R. et al. Relation between effective radiation dose and outcome of radioiodine therapy for thyroid cancer. N. Engl. J. Med. 309, 937–941 (1983).
Cobleigh et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic beast cancer that has progressed after chemotherapy for metastatic disease. J. Clin. Oncol. 17, 2639–2648 ( 1999).
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Daniels, G., Haber, D. Will radioiodine be useful in treatment of breast cancer?. Nat Med 6, 859–860 (2000). https://doi.org/10.1038/78604
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DOI: https://doi.org/10.1038/78604
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