A new generation of NSAIDs selectively and irreversibly inhibits cyclooxygenase-2—an enzyme that regulates several cellular processes involved in colon cancer development including angiogenesis.
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Rustgi, A. Cyclooxygenase-2: The future is now. Nat Med 4, 773–774 (1998). https://doi.org/10.1038/nm0798-773
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DOI: https://doi.org/10.1038/nm0798-773