Resurrecting the 'yuppie vaccine'

  • A Correction to this article was published on 08 October 2014

The only vaccine ever approved to protect against Lyme disease was pulled off the market in 2002, and drugmakers have yet to offer an alternative. What's taking so long? Cassandra Willyard investigates.

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  • 22 September 2014

     In the July 2014 issue, the piece “Resurrecting the 'yuppie vaccine'” (Nat. Med. 20, 698, 2014) stated that “LYMErix originated in the late 1980s in a laboratory at the Yale School of Medicine at Yale University” and that “[b]y 1992, SmithKline Beecham had licensed the vaccine.” However, it failed to mention the work of a team of German researchers, including Markus Simon and Ulrich Schaible at the Max Planck Institute and Michael Kramer and Reinhard Wallich of the University of Heidelberg, who published initial key findings laying the groundwork for the LYMErix vaccine against Lyme disease. The error has been corrected in the HTML and PDF versions of this article.


  1. 1

    Fikrig E., Barthold, S.W. & Flavell, R.A. Science 250, 553–556 (1990).

  2. 2

    Steere, A.C. et al. N. Engl. J. Med. 339, 209–215 (1998).

  3. 3

    Gross, D.M. et al. Science 281, 703–706 (1998).

  4. 4

    Poland, G.A. Clin. Infect. Dis. 52 (suppl. 3), s253–s258 (2011).

  5. 5

    Silverman, E. The Star-Ledger (26 February 2002).

  6. 6

    Sigal, L.H. et al. N. Engl. J. Med. 339, 216–222 (1998).

  7. 7

    Luft, B.J., Dunn, J.J. & Lawson, C.L. J. Infect. Dis. 185 (suppl. 1), S46–S51 (2002).

  8. 8

    Wressnigg, N. et al. The Lancet 13, 680–689 (2013).

  9. 9

    Small C.M., Ajithdoss, D.K., Rodrigues Hoffmann, A., Mwangi, W. & Esteve-Gassent M.D. PLoS One 9, e88245 (2014).

  10. 10

    Steere, A.C., Drouin, E.E. & Glickstein, L.J. Clin. Infect. Dis. 52 (suppl. 3), s259–s265 (2011).

  11. 11

    Stricker, R.B. & Johnson, L. Lancet Infect. Dis. 14, 12 (2014).

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Willyard, C. Resurrecting the 'yuppie vaccine'. Nat Med 20, 698–701 (2014).

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