Findings in mice and people suggest that glycosphingolipids have a role in the formation of large fluid-filled cysts in polycystic kidney disease. An inhibitor of glycosphingolipid synthesis may provide a potential therapy for this disorder, which often progresses to kidney failure (pages 788–792).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Katie Vicari
References
Rani, C.S. et al. J. Biol. Chem. 270, 2859–2867 (1995).
Cuvillier, O. et al. Nature 381, 800–803 (1996).
Lahiri, S. & Futerman, A.H. Cell. Mol. Life Sci. 64, 2270–2284 (2007).
Natoli, T.A. Nat. Med. 16, 788–792 (2010).
D'Agati, V.D., Jennette, J.C. & Silva, F.G. Atlas of Nontumor Pathology: Non-Neoplastic Kidney Disease. 721 (American Registry of Pathology Press, Maryland, 2005).
Torres, V.E. & Grantham, J.J. Brenner & Rector's The Kidney. Ch. 41 1428–1462 (W.B. Saunders Company, Boston, 2000).
Wilson, P.D. N. Engl. J. Med. 350, 151–164 (2004).
Gabow, P.A. N. Engl. J. Med. 329, 332–342 (1993).
Rinkel, G.J., Djibuti, M., Algra, A. & van Gijn, J. Stroke 29, 251–256 (1998).
Torres, V.E. & Harris, P.C. Kidney Int. 76, 149–168 (2009).
Torres, V.E., Harris, P.C. & Pirson, Y. Lancet 369, 1287–1301 (2007).
Jennemann, R. et al. Proc. Natl. Acad. Sci. USA 102, 12459–12464 (2005).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Takiar, V., Caplan, M. Telling kidneys to cease and decyst. Nat Med 16, 751–752 (2010). https://doi.org/10.1038/nm0710-751
Issue Date:
DOI: https://doi.org/10.1038/nm0710-751
