Gallstone disease occurs more frequently in subjects with the metabolic syndrome and type 2 diabetes. Findings in a mouse model suggest that the forkhead transcription factor FoxO1 lies behind this association (pages 778–782).
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Kuipers, F., Groen, A. Chipping away at gallstones. Nat Med 14, 715–716 (2008). https://doi.org/10.1038/nm0708-715
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DOI: https://doi.org/10.1038/nm0708-715
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Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEP
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