Rejuvenating premature aging

Two commonly prescribed drugs, statins and aminobisphosphonates, may be helpful in combating the rare aging disorder, Hutchinson-Gilford progeria syndrome (pages 767–772).

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Lamin A modifications in a model of HGPS.

Katie Ris-Vicari

References

  1. 1

    Varela, I. et al. Nat. Med. 14, 769–774 (2008).

  2. 2

    Navarro, C.L., Cau, P. & Lévy, N. Hum. Mol. Genet. 15, R151–R161 (2006).

  3. 3

    Gruenbaum, Y., Margalit, A., Goldman, R.D., Shumaker, D.K. & Wilson, K.L. Nat. Rev. Mol. Cell Biol. 6, 21–31 (2005).

  4. 4

    Dechat, T. et al. Genes Dev. 22, 832–853 (2008).

  5. 5

    Rusiñol, A.E. & Sinensky, M.S. J. Cell Sci. 119, 3265–3272 (2006).

  6. 6

    Dechat, T. et al. Proc. Natl. Acad. Sci. USA 104, 4955–4960 (2007).

  7. 7

    Stewart, C.L., Kozlov, S., Fong, L.G. & Young, S.G. Exp. Cell Res. 313, 2144–2156 (2007).

  8. 8

    Varela, I. et al. Nature 437, 564–568 (2005).

  9. 9

    Meta, M., Yang, S.H., Bergo, M.O., Fong, L.G. & Young, S.G. Trends Mol. Med. 12, 480–487 (2006).

  10. 10

    Yang, S.H. et al. J. Clin. Invest. 116, 2115–2121 (2006).

  11. 11

    Fong, L.G. et al. Science 311, 1621–1623 (2006).

  12. 12

    Whyte, D.B. et al. J. Biol. Chem. 272, 14459–14464 (1997).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Meshorer, E., Gruenbaum, Y. Rejuvenating premature aging. Nat Med 14, 713–715 (2008). https://doi.org/10.1038/nm0708-713

Download citation

Further reading