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Phosphoinositides' link to neurodegeneration

Mutations in the phosphoinositide metabolism gene FIG4 disrupt the endosomal pathway, leading to neurodegeneration and a newly identified variant of Charcot-Marie-Tooth disorder.

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Figure 1: Phosphoinositide composition of membranes along the endocytic pathway, including the localization of phosphatidylinositol-3-phosphate (PI3P) and the putative localization of phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2).

Katie Ris

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Volpicelli-Daley, L., De Camilli, P. Phosphoinositides' link to neurodegeneration. Nat Med 13, 784–786 (2007). https://doi.org/10.1038/nm0707-784

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