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Turning skin into embryonic stem cells

Introducing four genes into mouse skin fibroblasts reprograms these cells into embryonic stem cells. If similar techniques work in human cells, patient-specific stem cells for tissue engineering and cell-based therapies may be closer to reality.

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Figure 1: Hypothetical strategy for using iPS cells in cell-based therapies.

Katie Ris

References

  1. Okita, K., Ichisaka, T. & Yamanaka, S. Nature advance online publication, 6 June 2007 (doi:10.1038/nature05934).

    Article  CAS  Google Scholar 

  2. Wernig, M. et al. Nature advance online publication, 6 June 2007 (doi:10.1038/nature05944).

    Article  CAS  Google Scholar 

  3. Maherali, N. et al. Cell Stem Cell 1, 55–70 (2007).

    Article  CAS  Google Scholar 

  4. Rideout, W.M. III, Hochedlinger, K., Kyba, M., Daley, G.Q. & Jaenisch, R. Cell 109, 17–27 (2002).

    Article  CAS  Google Scholar 

  5. Campbell, K.H., McWhir, J., Ritchie, W.A. & Wilmut, I. Nature 380, 64–66 (1996).

    Article  CAS  Google Scholar 

  6. Jaenisch, R. N. Engl. J. Med. 351, 2787–2791 (2004).

    Article  CAS  Google Scholar 

  7. Egli, D., Rosains, J., Birkhoff, G. & Eggan, K. Nature 447, 679–685 (2007).

    Article  CAS  Google Scholar 

  8. Cowan, C.A., Atienza, J., Melton, D.A. & Eggan, K. Science 309, 1369–1373 (2005).

    Article  CAS  Google Scholar 

  9. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  10. Schmidt, E.V. Oncogene 18, 2988–2996 (1999).

    Article  CAS  Google Scholar 

  11. Hochedlinger, K., Yamada, Y., Beard, C. & Jaenisch, R. Cell 121, 465–477 (2005).

    Article  CAS  Google Scholar 

  12. Chang, H.Y. et al. Proc. Natl. Acad. Sci. USA 99, 12877–12882 (2002).

    Article  CAS  Google Scholar 

Download references

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Chang, H., Cotsarelis, G. Turning skin into embryonic stem cells. Nat Med 13, 783–784 (2007). https://doi.org/10.1038/nm0707-783

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  • DOI: https://doi.org/10.1038/nm0707-783

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