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Cracking the fungal armor

Fungal cell-wall polymers are potent stimulators of immune responses. New findings reveal that fungi shield inflammatory cell-wall polysaccharides from immune recognition, a process that is disrupted by an antifungal compound.

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Figure 1: C. albicans β-glucan is concealed beneath a mannan layer within the cell wall.

Kim Caesar

References

  1. Wheeler, R.T. & Fink, G.R. PLoS Pathog. 2, e35 (2006).

    Article  Google Scholar 

  2. Tzianabos, A.O. Clin. Microbiol. Rev. 13, 523–533 (2000).

    Article  CAS  Google Scholar 

  3. Brown, G.D. & Gordon, S. Immunity 19, 311–315 (2003).

    Article  CAS  Google Scholar 

  4. Brown, G.D. & Gordon, S. Nature 413, 36–37 (2001).

    Article  CAS  Google Scholar 

  5. Brown, G.D. Nat. Rev. Immunol. 6, 33–43 (2006).

    Article  CAS  Google Scholar 

  6. Gantner, B.N., Simmons, R.M. & Underhill, D.M. EMBO J. 24, 1277–1286 (2005).

    Article  CAS  Google Scholar 

  7. Steele, C. et al. J. Exp. Med. 198, 1677–1688 (2003).

    Article  CAS  Google Scholar 

  8. Viriyakosol, S., Fierer, J., Brown, G.D. & Kirkland, T.N. Infect. Immun. 73, 1553–1560 (2005).

    Article  CAS  Google Scholar 

  9. Hohl, T.M. et al. PLoS Pathog 1, e30 (2005).

    Article  Google Scholar 

  10. Steele, C. et al. PLoS Pathog. 1, e42 (2005).

    Article  Google Scholar 

  11. Gersuk, G.M., Underhill, D.M., Zhu, L. & Marr, K.A. J. Immunol. 176, 3717–3724 (2006).

    Article  CAS  Google Scholar 

  12. Herrero, A.B. et al. Eukaryot. Cell 3, 1423–1432 (2004).

    Article  CAS  Google Scholar 

  13. De Bernardis, F., Muhlschlegel, F.A., Cassone, A. & Fonzi, W.A. Infect. Immun. 66, 3317–3325 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Hohl, T., Pamer, E. Cracking the fungal armor. Nat Med 12, 730–732 (2006). https://doi.org/10.1038/nm0706-730

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