PPARα reduces fat accumulation and enhances insulin sensitivity, but exactly how it operates has been unclear. Work on mice suggests that newly synthesized fat—but not preexisting fat—activates this transcription factor.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Unger, R.H. Annu. Rev. Med. 53, 319–336 (2002).
Lin, H.Z. et al. Nat. Med. 6, 998–1003 (2000).
Hellerstein, M.K., Schwarz, J.M. & Neese, R.A. Annu. Rev. Nutr. 16, 523–557 (1996).
Chakravarthy, M.V. et al. Cell Metabolism 1, 309–322 (2005).
Kersten, S. et al. J. Clin. Invest. 103, 1489–1498 (1999).
Zhou, G. et al. J. Clin. Invest. 108, 1167–1174 (2001).
Lee, Y. et al. Proc. Natl. Acad. Sci. USA 99, 11848–11853 (2002).
Gibbons, G.F., Islam, K. & Pease, R.J. Biochim. Biophys. Acta 1483, 37–57 (2000).
Patel, D.D., Knight, B.L., Wiggins, D., Humphreys, S.M. & Gibbons, G.F. J. Lipid Res. 42, 328–337 (2001).
Rawson, R.B. Nat. Rev. Mol. Cell Biol. 4, 631–640 (2003).
Friedman, J. Nature 415, 268–269 (2002).
Guerre Millo, M. et al. Diabetes 50, 2809–2814 (2001).
Kopelman, P.G. Nature 404, 635–643 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gibbons, G. Old fat, make way for new fat. Nat Med 11, 722–723 (2005). https://doi.org/10.1038/nm0705-722
Issue Date:
DOI: https://doi.org/10.1038/nm0705-722
This article is cited by
-
Fat poetry: a kingdom for PPARγ
Cell Research (2007)
-
Signalling mechanisms linking hepatic glucose and lipid metabolism
Diabetologia (2006)
-
Erratum: Corrigendum: Old fat, make way for new fat
Nature Medicine (2005)