Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Rules of conduct for the cystic fibrosis anion channel

Nature Medicine volume 9, pages 827–828 (2003)Cite this article

Improper ion balance resulting from defects in the ion channel CFTR underlies cystic fibrosis. Separate control mechanisms are now shown to regulate the flux of chloride and bicarbonate through this channel.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: New controls of CFTR-dependent activity and conductance in the human sweat duct.

References

  1. Reddy, M.M. & Quinton, P.M. Control of dynamic CFTR selectivity by glutamate & ATPin epithelial cells. Nature 423, 757–760 (2003).

    Article  Google Scholar 

  2. Choi, J.Y. et al. Aberrant CFTR-dependent HCO3− transport in mutations associated with cystic fibrosis. Nature 410, 94–97 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ko, S.B. et al. A molecular mechanism for aberrant CFTR-dependent HCO3− transport in cystic fibrosis. EMBO J. 21, 5662–5672 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Vergani, P., Nairn, A.C. & Gadsby, D.C. On the mechanism of MgATP-dependent gating of CFTR Cl− channels. J. Gen. Physiol. 121, 17–36 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Aleksandrov, A.A., Chang, X., Aleksandrov, L. & Riordan, J.R. The non-hydrolytic pathway of cystic fibrosis transmembrane conductance regulator ion channel gating. J. Physiol. 528, 259–265 (2000).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Hille, B. Ion Channels of Excitable Membranes, 814 (Sinauer, Sunderland, Massachusetts, 2001).

    Google Scholar 

  7. Doyle, D.A. et al. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280, 69–77 (1998).

    Article  CAS  PubMed  Google Scholar 

  8. Dutzler, R., Campbell, E.B. & MacKinnon, R. Gating the selectivity filter in ClC chloride channels. Science 300, 108–112 (2003).

    Article  CAS  PubMed  Google Scholar 

  9. Kogan, I. et al. CFTR directly mediates nucleotide-regulated glutathione flux. EMBO J. 22, 1981–1989 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The author is in the Department of Psychology, Cystic Fibrosis Research Lab, Stanford University, Stanford, 94305-2130, California, USA

    Jeffrey J Wine

Authors
  1. Jeffrey J Wine
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wine, J. Rules of conduct for the cystic fibrosis anion channel. Nat Med 9, 827–828 (2003). https://doi.org/10.1038/nm0703-827

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0703-827

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing