Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Dengue immune response: low affinity, high febrility

Nature Medicine volume 9, pages 820–822 (2003)Cite this article

Immunity built up after dengue virus infection protects only poorly against reinfection by a virus of a different serotype, and second infections are often even more severe. A new study examines why (pages 921–927).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Low-affinity T-cell response to dengue antigens after secondary (sequential) infection.

M.A. Brehm

References

  1. Thein, S. et al. Risk factors in dengue shock syndrome. Am. J. Trop. Med. Hyg. 56, 566–572 (1997).

    Article  CAS  Google Scholar 

  2. Mongkolsapaya, J. et al. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat. Med. 9, 921–927 (2003).

    Article  CAS  Google Scholar 

  3. Gubler, D.J. Dengue and dengue hemorrhagic fever. Clin. Microbiol. Rev. 11, 480–496 (1998).

    Article  CAS  Google Scholar 

  4. Morens, D.M. Antibody-dependent enhancement of infection and the pathogenesis of viral disease. Clin. Infect. Dis. 19, 500–512 (1994).

    Article  CAS  Google Scholar 

  5. Libraty, D.H. et al. Differing influences of viral burden and immune activation on disease severity in secondary dengue 3 virus infections. J. Infect. Dis. 185, 1213–1221 (2002).

    Article  Google Scholar 

  6. Zivny, J. et al. Partial agonist effect influences the CTL response to a heterologous dengue virus serotype. J. Immunol. 163, 2754–2760 (1999).

    CAS  PubMed  Google Scholar 

  7. Klenerman, P. & Zinkernagel, R.M. Original antigen sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature 394, 482–485 (1998).

    Article  CAS  Google Scholar 

  8. Brehm, M.A. et al. T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens. Nat. Immunol. 3, 627–634 (2002).

    Article  CAS  Google Scholar 

  9. Yewdell, J.W. & Bennink, J.R. Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses. Annu. Rev. Immunol. 17, 51–88 (1999).

    Article  CAS  Google Scholar 

  10. Welsh, R.M. & Selin, L.K. No one is naive: the significance of heterologous T-cell immunity. Nat. Rev. Immunol. 2, 417–426 (2002).

    Article  CAS  Google Scholar 

  11. Combadiere, B., Sousa, C.R., Germain, R.N. & Lenardo, M.J. Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands. J. Exp. Med. 187, 349–355 (1998).

    Article  Google Scholar 

  12. von Herrath, M.G. & Oldstone, M.B. Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185, 531–539 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pathology and Medicine, University of Massachusetts Medical School, Worcester, 01655, Massachusetts, USA

    Raymond M Welsh & Alan L Rothman

Authors
  1. Raymond M Welsh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alan L Rothman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Welsh, R., Rothman, A. Dengue immune response: low affinity, high febrility. Nat Med 9, 820–822 (2003). https://doi.org/10.1038/nm0703-820

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0703-820

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing