Immunologists are just beginning to understand the early signals required to recruit memory T cells to sites of antigen-specific inflammation. Now it seems that activation of κ light chain–sensitized mast cells by antigen-specific recognition initiates local immune responses (pages 694–701).
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References
Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245–252 (1998).
Fuchs, E.J. & Matzinger, P. B cells turn off virgin but not memory T cells. Science 258, 56–59 (1992).
Qin, Z. et al. B cells inhibit induction of T cell-dependent tumor immunity. Nature Med. 4, 627–630 (1998).
Tsuji, R.F. et al. Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity, and late T cell interferon γ: A possible initiating role of B cells. J. Exp. Med. 186, 1015–1026 (1997).
Redegeld, F.A. et al. Immunoglobulin free light chains elicit immediate hypersensitivity-like responses. Nature Med. 8,694–701 (2002).
Wedemeyer, J., Tsai, M. & Galli, S.J. Roles of mast cells and basophils in innate and acquired immunity. Curr. Opin. Immunol. 12, 624–631 (2000).
Stassen, M., Hültner, L. & Schmitt, E. Classical and alternative pathways of mast cell activation. Crit. Rev. Immunol. (in the press).
Biedermann T. et al. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. J. Exp. Med. 192, 1441–1452 (2000).
Biedermann, T. et al. Interleukin 4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nature Immunol. 2, 1054–1060 (2001).
Kunkel, E.J. & Butcher, E.C. Chemokines and the tissue-specific migration of lymphocytes. Immunity 16, 1–4 (2002).
Ohashi, P.S. et al. Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65, 305–317 (1991).
Limmer, A. et al. Failure to induce organ-specific autoimmunity by breaking of tolerance: Importance of the microenvironment. Eur. J. Immunol. 28, 2395–2406 (1998).
McHale, J.F. et al. Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice: Evidence for a dominant role of TNF-α. J. Immunol. 162, 1648–1655 (1999).
Secor, V.H. et al. Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis. J. Exp. Med. 191, 813–821 (2000).
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Röcken, M., Hültner, L. Heavy functions for light chains. Nat Med 8, 668–670 (2002). https://doi.org/10.1038/nm0702-668
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DOI: https://doi.org/10.1038/nm0702-668
