Many premature infants have deficient pulmonary surfactant, which is required to reduce surface tension and prevent lungs from collapsing. A recent study may provide a new avenue for therapy by showing that vascular endothelial growth factor (VEGF) helps to regulate surfactant production. When given to premature mice near birth, VEGF can reduce symptoms of surfactant deficiency and relieve respiratory distress (pages 702–710).
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Coutesy of Veerle Compernoole
Coutesy of Till Acker
References
Pattle, R.E. Properties, function and origin of the alveolar lining layer. Nature 175, 1125–1126 (1955).
Clements, J.A. Surface tension of lung extracts. Proc. Soc. Exp. Biol. Med. 95, 170–172 (1957).
Avery, M.E. & Mead, J. Surface properties in relation to atelectasis and hyaline membrane disease. Am. J. Dis. Child 97, 517–523 (1959).
Liggins, G.C. Premature delivery of foetal lambs infused with glucocorticoids. J. Endocrinol 45, 515–523 (1969).
Liggins, G.C. & Howie, R.N. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 50, 515–525 (1972).
Fujiwara, T. et al. Artificial surfactant therapy in hyaline membrane disease. Lancet 1, 55–59 (1980).
Compernolle, V. et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, while treatment with VEGF prevents fatal respiratory distress in premature mice. Nature Med 8, 702–710 (2002).
Bland, R.D. & Nielson, D.W. Developmental changes in lung epithelial ion transport and liquid movement. Annu. Rev. Physiol. 54, 373–394 (1992).
Northway, W.H. Jr et al. Late pulmonary sequelae of bronchopulmonary dysplasia. New Engl. J. Med. 323, 1793–1799 (1990).
Coalson, J.J. Pathology of chronic lung disease of early infancy. in Chronic Lung Disease in Early Infancy. Vol. 137 of Lung Biology in Health and Disease. (series; eds. Bland, R.D. & Coalson, J.J.) 85–124 (Marcel Dekker Inc., New York, 2000).
Bhatt, A.J. et al. Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, flt-1, and tie-2 in human infants dying with bronchopulmonary dysplasia. Am. J. Respir. Crit. Care Med. 164, 1971–1980 (2001).
Coalson, J.J., Winter, V.T., Siler-Khodr, T. & Yoder, B.A. Neonatal chronic lung disease in extremely immature baboons. Am. J. Respir. Crit. Care Med. 160, 1333–1346 (1999).
Albertine, K.H. et al. Chronic lung injury in preterm lambs. Disordered respiratory tract development. Am. J. Respir. Crit. Care Med. 159, 945–958 (1999)
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Rabinovitch, M., Bland, R. Novel notions on newborn lung disease. Nat Med 8, 664–666 (2002). https://doi.org/10.1038/nm0702-664
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DOI: https://doi.org/10.1038/nm0702-664
