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Blasting away leukemia

Nature Medicine volume 5, pages 619–620 (1999)Cite this article

Abstract

CD44 delivers a differentiation signal to leukemic blast cells that may be exploited to create new therapies for acute myeloid leukemia (pages 669–676).

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References

  1. Lesley, J., Hyman, R. & Kincade, P.W. CD44 and its interaction with the extracellular matrix. Adv. Immunol. 54, 271– 335 (1993).

    Article  CAS  Google Scholar 

  2. Gunthert, U. et al. A new variant of Glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65, 13– 24 (1991).

    Article  CAS  Google Scholar 

  3. Sy, M.-S., Guo, Y.-J. & Stamenkovic, I. Inhibition of tumor growth in vivo with a soluble CD44- immunoglobulin fusion protein. J. Exp. Med. 176, 623–627 (1992).

    Article  CAS  Google Scholar 

  4. Charrad, R.-S. et al. Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia. Nature Med. 5, 669–676 (1999).

    Article  CAS  Google Scholar 

  5. Zheng, Z. et al. Monoclonal antibodies to CD44 and their influence on hyaluronan recognition. J. Cell Biol 130, 485– 495 (1995).

    Article  CAS  Google Scholar 

  6. McKee, C.M. et al. Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. J. Clin. Invest. 98, 2403–2413 (1996).

    Article  CAS  Google Scholar 

  7. Schmits, R. et al. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90, 2217–2233 (1997).

    CAS  Google Scholar 

  8. Sandmaier, B.M., Storb, R., Appelbaum, F.R. & Gallatin, W.M. An antibody that facilitates hematopoietic engraftment recognizes CD44. Blood 76, 630–635 ( 1990).

    CAS  PubMed  Google Scholar 

  9. Mikecz, K., Brennan, F.R., Kim, J.H. & Giant, T.T. Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nature Med. 1, 558–563 ( 1995).

    Article  CAS  Google Scholar 

  10. Camp, R.L., Scheynius, A., Johansson, C. & Pure, E. CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation. J. Exp. Med. 178 , 497–507 (1993).

    Article  CAS  Google Scholar 

  11. DeGrendele, H.C., Estess, P. & Siegelman, M.H. Requirement for CD44 in activated T cell extravasation into an inflammatory site. Science 278, 672–675 (1997).

    Article  CAS  Google Scholar 

  12. Kincade, P.W., Zheng, Z., Katoh, S. & Hanson, L. The importance of cellular environment to function of the CD44 matrix receptor. Curr. Opin. Cell Biol. 9, 635–642 (1997).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, 73104, Oklahoma, USA

    Paul W. Kincade

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  1. Paul W. Kincade
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Kincade, P. Blasting away leukemia. Nat Med 5, 619–620 (1999). https://doi.org/10.1038/9462

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