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The NOD mouse model of type 1 diabetes: As good as it gets?

Abstract

Of the two well-known rodent models of human type 1 diabetes (the non-obese diabetic mouse and the BioBreeding rat) the mouse has become the model of choice. Here the authors re-examine the value of this mouse model as a tool for understanding human diabetes and for testing potential therapies, reviewing both strengths and weaknesses.

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Figure 1: Insulitis in humans and NOD mouse pancreas.

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Atkinson, M., Leiter, E. The NOD mouse model of type 1 diabetes: As good as it gets?. Nat Med 5, 601–604 (1999). https://doi.org/10.1038/9442

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