Protection against enteric pathogens may partly explain the proposed heterozygote advantage of cystic fibrosis mutations in certain populations.
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References
Rommens, J.M. et al. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 245, 1059–1072 (1989).
Pier, G.B. et al. Salmonella typhi uses CFTR to enter intestinal epithelial cells. Nature 393, 79–82 (1998).
Saiman, L. & Prince, A. Pseudomonas aeruginosa pili bind to asialoGM1 which is increased on the surface of cystic fibrosis epithelial cells. J. Clin. Invest. 92, 1875–1880 (1993).
Pier, G.B., Grout, M. & Zaidi, T.S. Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung. Proc. Natl. Acad. Sci. USA 4, 12088–12093 (1997).
Smith, J.J., Travis, S.M., Greenberg, E.P. & Welsh, M.J. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85, 229–236 (1996).
Trezise, A.E. & Buchwald, M. In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator. Nature 353, 434–435. (1991).
Ameen, N.A., Ardito, T., Kashgarian, M. & Marino, C.R. A unique subset of rat and human intestinal villus cells express the cystic fibrosis transmembrane conductance regulator. Gastroenterol. 108, 1016–1023.(1995).
Jones, B.D. & Falkow, S. Salmonellosis: host immune responses and bacterial virulence determinants. Annu. Rev. Immunol. 14, 533–561 (1996).
Weinstein, D.L., O'Neill, B.L., Hone, D.M. & Metcalf, E.S. Differential early interactions between Salmonella enterica serovar typhi and two other pathogenic Salmonella serovars with intestinal epithelial cells. Infect. Immun. 66, 2310–2318 (1998).
Gabriel, S.E., Brigman, K.N., Koller, B.H., Boucher, R.C. & Stutts, M.J. Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model. Science 266, 107–109 (1994).
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Prince, A. The CFTR advantae-capitalizing on a quirk of fate. Nat Med 4, 663–664 (1998). https://doi.org/10.1038/nm0698-663
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DOI: https://doi.org/10.1038/nm0698-663
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