Transgenic mice that overexpress calcineurin develop cardiac hypertrophy, which can be prevented by treatment with immunosuppressive drugs that inhibit calcineurin.
Subscribe to Journal
Get full journal access for 1 year
only $18.75 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
All prices are NET prices.
Molkentin, J.D. et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215–228 (1998).
Sadoshima, J. & Izumo, S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu. Rev. Physiol. 59, 551–571 (1997).
Gruver, C.L., DeMayo, F., Goldstein, M.A. & Means, A.R. Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice. Endocrinology 133, 376–388 (1993).
Morgan, J.P., Erny, R.E., Allen, P.D., Grossman, W. & Gwathmey, J.K. Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation 81, 21–32 (1990).
Takahashi, T. et al. Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. J. Clin. Invest. 90, 927–935 (1992).
Herzig, T.C. et al. Angiotensin II type 1α receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proc. Natl. Acad. Sci. USA 94, 7543–7548 (1997).
Rao, A., Luo, C. & Hogan, P.G. Transcription factors of the NF-AT family: Regulation and function. Annu. Rev. Immunol. 15, 707–747 (1997).
Schreiber, S.L. & Crabtree, G.R. The mechanism of action of cyclosporin A and FK506. Immunol. Today 13, 136–142 (1992).
Katz, A.M. Cardiomyopathy of overload. A major determinant of prognosis in congestive heart failure. N. Engl. J. Med. 322, 100–110 (1990).
Dolmetsch, R.E., Lewis, R.S., Goodnow, C.C. & Healy, J.I. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 386, 855–858 (1997).
Mason, J.W. et al. A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. N. Engl. J. Med. 333, 269–275 (1995).
About this article
Scientific Reports (2018)
Selective Modulation of Nuclear Factor of Activated T-Cell Function in Restenosis by a Potent Bipartite Peptide Inhibitor
Circulation Research (2012)
Arteriosclerosis, Thrombosis, and Vascular Biology (2011)
Journal of the Korean Society of Hypertension (2011)
Clinical Lipidology (2009)