Calcineurin—the missing link in cardiac hypertrophy

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Transgenic mice that overexpress calcineurin develop cardiac hypertrophy, which can be prevented by treatment with immunosuppressive drugs that inhibit calcineurin.

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References

  1. 1

    Molkentin, J.D. et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215–228 (1998).

  2. 2

    Sadoshima, J. & Izumo, S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu. Rev. Physiol. 59, 551–571 (1997).

  3. 3

    Gruver, C.L., DeMayo, F., Goldstein, M.A. & Means, A.R. Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice. Endocrinology 133, 376–388 (1993).

  4. 4

    Morgan, J.P., Erny, R.E., Allen, P.D., Grossman, W. & Gwathmey, J.K. Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation 81, 21–32 (1990).

  5. 5

    Takahashi, T. et al. Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. J. Clin. Invest. 90, 927–935 (1992).

  6. 6

    Herzig, T.C. et al. Angiotensin II type 1α receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proc. Natl. Acad. Sci. USA 94, 7543–7548 (1997).

  7. 7

    Rao, A., Luo, C. & Hogan, P.G. Transcription factors of the NF-AT family: Regulation and function. Annu. Rev. Immunol. 15, 707–747 (1997).

  8. 8

    Schreiber, S.L. & Crabtree, G.R. The mechanism of action of cyclosporin A and FK506. Immunol. Today 13, 136–142 (1992).

  9. 9

    Katz, A.M. Cardiomyopathy of overload. A major determinant of prognosis in congestive heart failure. N. Engl. J. Med. 322, 100–110 (1990).

  10. 10

    Dolmetsch, R.E., Lewis, R.S., Goodnow, C.C. & Healy, J.I. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 386, 855–858 (1997).

  11. 11

    Mason, J.W. et al. A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. N. Engl. J. Med. 333, 269–275 (1995).

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Izumo, S., Aoki, H. Calcineurin—the missing link in cardiac hypertrophy. Nat Med 4, 661–662 (1998) doi:10.1038/nm0698-661

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