A role for IL-15 in rheumatoid arthritis?

Article metrics

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    McInnes, I.B. et al. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nature Med. 2,175–182 (1996).

  2. 2

    McInnes, I.B. et al. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-(production in rheumatoid arthritis. Nature Med. 3, 189–195 (1997).

  3. 3

    Malyak M. et al. IL-1 ra ELISA: reduction and alkylation of synovial fluid eliminates interference by IgM rheumatoid factors. J. Imm. Methods. 140, 281–288 (1991).

  4. 4

    Al-Mughales J. et al. The chemoattractant activity of rheumatoid synovial fluid for human lymphocytes is due to multiple cytokines. Clin. Exp. Immunol. 106, 230–236(1996).

  5. 5

    Kotake, S. et al. In vivo gene expression of type 1 and type 2 cytokines in synovial tissues from patients in early stages of rheumatoid, reactive, and undifferentiated arthritis. Proc. Assoc. Am. Physicians. 109, 286–301 (1997).

  6. 6

    Thurkow, E.W. et al. Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis. J. Pathol. 181, 444–450 (1997).

  7. 7

    Kaplan, D. Autocrine secretion and the physiological concentration of cytokines. Immunol. Today 17, 303–304 (1996).

  8. 8

    Sebbag, M. et al. Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-alpha, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis. Eur. J. Immunol. 27, 624–632 (1997).

  9. 9

    Ruchatz, H. et al. Soluble interleukin-15 (IL-15) receptor a chain administration prevents murine collagen-induced arthritis - a role for IL-15 in development of antigen-induced immunopathology.J. Immunol. (in the press).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Shah, M., Hackshaw, K. & Caligiuri, M. A role for IL-15 in rheumatoid arthritis?. Nat Med 4, 643 (1998) doi:10.1038/nm0698-643a

Download citation

Further reading