The induction of ulcerative colitis in mice with targeted disruptions of a G protein-encoding gene establishes yet another genetic link between G proteins and disease.
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References
Rudolph, U. et al. Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice. Nature Genet. 10, 141–148 (1995).
Spiegel, A.M., Jones, T.L.Z., Simonds, W.F. & Weinstein, L.S. G Proteins (R.G. Landes, Austin, Texas, 1994).
Neer, E.J. Heterotrimeric G proteins: Organizers of transmembrane signals. Cell 80, 249–257 (1995).
Bichet, D.G. et al. Nature and recurrence of AVPR2 mutations in X-linked nephrogenic diabetes insipidus. Am. J. hum. Genet. 55, 278–286 (1994).
Puffenberger, E.G. et al. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell 79, 1257–1266 (1994).
Spiegel, A.M., Weinstein, L.S. & Shenker, A. Abnormalities in G protein-coupled signal transduction pathways in human disease. J. clin. Invest. 92, 1119–1125 (1993).
Parma, J. et al. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 365, 649–651 (1993).
Lyons, J. et al. Two G protein oncogenes in human endocrine tumors. Science 249, 655–659 (1990).
Weinstein, L.S. et al. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. New Engl. J. Med. 325, 1688–1695 (1991).
Raymond, J.R. et al. Alpha 2A adrenergic receptors inhibit cAMP accumulation in embryonic stem cells which lack Gi alpha 2. J. biol. Chem. 269, 13073–13075 (1994).
Goldsmith, P. et al. Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain. J. biol. Chem. 262, 14683–14688 (1987).
Montmayeur, J.P. & Borrelli, E. Targeting of Gαi2 to the Golgi by alternative spliced carboxylterminal region. Science 263, 95–98 (1994).
Moxham, C.M., Hod, Y. & Malbon, C.C. Induction of Gαi2-specific antisense RNA in vivo inhibits neonatal growth. Science 260, 991–995 (1993).
Chaffin, K.E. & Perlmutter, R.M. A pertussis toxin-sensitive process controls thymocyte emigration. Eur. J. Immun. 21, 2565–2573 (1991).
Strober, W. & Ehrhardt, R.O. Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice. Cell 75, 203–205 (1993).
Elson, C.O. et al. in Inflammatory Bowel Disease (eds Sutherland, L.R., et al.) 81–87 (Kluwer Academic Publishers, Boston, Massachusetts, 1994).
Iisma, T.P., Biden, T.J. & Shine, J. G Protein-Coupled Receptors (R.G. Landes, Austin, Texas, 1995).
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Spiegel, A. G protein gene knockout hits the gut. Nat Med 1, 522–524 (1995). https://doi.org/10.1038/nm0695-522
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DOI: https://doi.org/10.1038/nm0695-522