Some individuals with estrogen receptor–α (ER-α)-positive breast cancer do not respond to tamoxifen treatment. Increased expression of the ubiquitin ligase CUEDC2 may contribute to this endocrine resistance by reducing theamounts of ER-α (pages 708–714).
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References
Early Breast Cancer Trialists' Collaborative Group. Lancet 365, 1687–1717 (2005).
Massarweh, S. & Schiff, R. Endocr. Relat. Cancer 13, Suppl. 1, S15–S24 (2006).
Musgrove, E.A. & Sutherland, R.L. Nat. Rev. Cancer 9, 631–643 (2009).
Pan, X. et al. Nat. Med. 17, 708–714 (2011).
Zhang, P.J. et al. EMBO J. 26, 1831–1842 (2007).
Zhao, J.J. et al. J. Biol. Chem. 283, 31079–31086 (2008).
Livasy, C.A. et al. Mod. Pathol. 19, 264–271 (2006).
Barone, I., Brusco, L. & Fuqua, S.A. Clin. Cancer Res. 16, 2702–2708 (2010).
Shi, L. et al. J. Clin. Oncol. 27, 3423–3429 (2009).
Shang, Y. Nat. Rev. Cancer 6, 360–368 (2006).
Arpino, G., Wiechmann, L., Osborne, C.K. & Schiff, R. Endocr. Rev. 29, 217–233 (2008).
Hurtado, A. et al. Nature 456, 663–666 (2008).
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Thomas, C., Gustafsson, JA. A CUE hints at tumor resistance. Nat Med 17, 658–660 (2011). https://doi.org/10.1038/nm0611-658
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DOI: https://doi.org/10.1038/nm0611-658
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