Activation of Toll-like receptor (TLR) signaling by microbes in the intestine promotes tumor growth in genetically susceptible mice. Inactivation of extracellular signal–regulated kinase (ERK), a molecule downstream of TLR signaling, may offer a route to preventing colorectal cancer (pages 665–670).
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Fukata, M., Abreu, M. Microflora in colorectal cancer: a friend to fear. Nat Med 16, 639–641 (2010). https://doi.org/10.1038/nm0610-639
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DOI: https://doi.org/10.1038/nm0610-639
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