Two clinical studies have identified mutations affecting the EGF receptor in lung cancers from patients who respond robustly to gefitinib, a small-molecule inhibitor of the receptor tyrosine kinase. This work highlights the importance of conducting clinical trials with an eye to delivering molecule-targeted therapeutics to those patients most likely to benefit.
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Arteaga, C. Selecting the right patient for tumor therapy. Nat Med 10, 577–578 (2004). https://doi.org/10.1038/nm0604-577
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DOI: https://doi.org/10.1038/nm0604-577
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