Abstract
Will new insights into Thalidomide's teratogenic mechanism help make its return a safe one (pages 582–585)?
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References
Lenz, W. Kindliche Missbildungen nach Medikament-Einnahme wahrend der Gravidtat? Dtsch. Med. Wochenschr. 86, 2555–2556 (1961).
McBride, W.G. Thalidomide and congenital anomalies. Lancet 2, 1358 (1961).
Castilla, E.E. et al. Thalidomide, a current teratogen in South America. Teratology 54, 273–277 ( 1996).
Stephens, T.D. Proposed mechanisms of action in thalidomide embryopathy. Teratology 38, 229–239 ( 1988).
Parman, T., Wiley, M.J. &. Wells, P.G. Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity. Nature Med. 5, 582–585 ( 1999).
Schardein, J. L. in Chemically induced Birth Defects, 2nd edition, Ch. 8, 208–270 ed. J.L. Schardein (Marcel Dekker, New York, 1993).
Arlen, R.R. & Wells, P.G. Inhibition of thalidomide teratogenicity by acetylsalicylic acid: evidence for prostaglandin H synthase-catalyzed bioactivation of thalidomide to a teratogenic reactive intermediate. J. Pharm. Exp. Ther. 277, 1649–1658 (1996).
Ozolins, T.R.S. & Hales, B.F. Glutathione homeostasis and the AP-1 response in the rat conceptus are regulated in a tissue-specific manner. Biochem. Pharmacol. (in the press).
Slott, V.L. & Hales, B.F. Effect of glutathione depletion by buthionine sulfoximine on rat embryonic development in vitro. Biochem. Pharmacol. 36, 683–688 (1987).
Salas-Vidal, E. et al. Reactive oxygen species participate in the control of mouse embryonic cell death. Exp. Cell Res. 238, 136–147 (1998).
Sampaio, E.P., Sarno, E.N., Galilly, R., Cohn, Z.A. & Kaplan, G. Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes. J. Exp. Med. 173, 699–703 (1991).
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Hales, B. Thalidomide on the comeback trail. Nat Med 5, 489–490 (1999). https://doi.org/10.1038/8371
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DOI: https://doi.org/10.1038/8371
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