Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neurotrophic factor therapy — Keeping score

Nature Medicine volume 3, pages 497–498 (1997)Cite this article

Implants of polymer-encapsulated cells producing CNTF protect neurons of the striatum and cortex from drug-induced destruction in a monkey model of Huntington's disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Gao, W.Q. et al. Neurotrophin-3 reverses cisplatin-induced peripheral sensory neuropathy. Ann. Neurol. 38, 30–37 (1995).

    Article  CAS  Google Scholar 

  2. Emerich, D.F. et al. Protective effect of encapsulated cells producing neurotrophic factor CNTF in monkey model of Huntington's disease. Nature 386, 395–399 (1997).

    Article  CAS  Google Scholar 

  3. Mangiarini, L. et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493–506 (1996).

    Article  CAS  Google Scholar 

  4. Goldberg, Y.P. et al. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nature Genet. 13, 442–449 (1996).

    Article  CAS  Google Scholar 

  5. Kuida, K. et al. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368–372 (1996).

    Article  CAS  Google Scholar 

  6. Burke, J.R. et al. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature Med. 2, 347–350 (1996).

    Article  CAS  Google Scholar 

  7. Koroshetz, W.J., Jenkins, B.G., Rosen, B.R. & Beal, M.F. Energy metabolism defects in Huntington's disease and effects of coenzyme Q10 . Ann. Neurol. 41, 160–165 (1997).

    Article  CAS  Google Scholar 

  8. Winkler, J. et al. Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor. Ann. Neurol. 41, 82–93 (1997).

    Article  CAS  Google Scholar 

  9. Gash, D.M. et al. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380, 252–256 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Merck Sharp & Dohme, Neuroscience Research Centre, Harlow, Essex, UK

    Franz Hefti

Authors
  1. Franz Hefti
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hefti, F. Neurotrophic factor therapy — Keeping score. Nat Med 3, 497–498 (1997). https://doi.org/10.1038/nm0597-497

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0597-497

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing