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Human TSE disease — viral or protein only?

Nature Medicine volume 3, pages 491–492 (1997)Cite this article

Analyses of prion protein deposits in patients with Creutzfeldt-Jakob disease contribute to the controversy over the nature of the transmissible agent (pages 521–525).

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References

  1. Caughey, B. & Chesebro, B. Prion protein and the transmissible spongiform encephalopathies. Trends Biol. Sci. 7, 56–62 (1997).

    Article  CAS  Google Scholar 

  2. Griffith, J.S. Self-replication and scrapie. Nature 215, 1043–1044 (1967).

    Article  CAS  Google Scholar 

  3. Prusiner, S.B. Novel proteinaceous infectious particles cause scrapie. Science 216, 136–144 (1982).

    Article  CAS  Google Scholar 

  4. Gajdusek, D.C. Transmissible and nontransmissible amyloidoses: Autocatalytic post-translational conversion of host precursor proteins to beta-pleated configurations. J. Neuroimmunol. 20, 95–110 (1988).

    Article  CAS  Google Scholar 

  5. Hsiao, K.K. et al. Spontaneous neurodegeneration in transgenic mice with mutant prion protein. Science 250, 1587–1590 (1990).

    Article  CAS  Google Scholar 

  6. Westaway, D. et al. Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins. Cell 76, 117–129 (1994).

    Article  CAS  Google Scholar 

  7. Hsiao, K.K. et al. Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein. Proc. Natl. Acad. Sci. USA 91, 9126–9130 (1994).

    Article  CAS  Google Scholar 

  8. Brown, P. et al. Human spongiform encephalopathy: The National Institutes of Health series of 300 cases of experimentally transmitted disease. Ann. Neurol. 35, 513–529 (1994).

    Article  CAS  Google Scholar 

  9. Silvestrini, M.C. et al. Identification of the prion protein allotypes that accumulate in the brain of sporadic and familial Creutzfeldt-jakob disease patients. Nature Med. 3, 521–525 (1997).

    Article  CAS  Google Scholar 

  10. Tagliavini, F. et al. Amyloid fibrils in Gerstmann-Straussler-Scheinker disease (Indiana and Swedish kindreds) express only PrP peptides encoded by the mutant allele. Cell 79, 695–703 (1994).

    Article  CAS  Google Scholar 

  11. Barbanti, P. et al. Polymorphism at codon 129 or codon 219 of PRNP and clinical heterogeneity in a previously unreported family with Gerstmann-Straussler-Scheinker disease (PrP-P102L mutation). Neurology 47, 734–741 (1996).

    Article  CAS  Google Scholar 

  12. Gabizon, R. et al. Insoluble wild-type and protease-resistant mutant protein in brains of patients with inherited prion disease. Nature Med. 2, 59–64 (1996).

    Article  CAS  Google Scholar 

  13. Kitamoto, T., Yamaguchi, K., Doh-ura, K. & Tateishi, J. A prion protein missense variant is integrated in kuru plaque cores in patients with Gerstmann-Straussler syndrome. Neurology 41, 306–310 (1991).

    Article  CAS  Google Scholar 

  14. Young, N.S., . in Fields Virology. (eds. Fields B.N., Knipe, D.M. & Howley P.M.) 2199–2220 (Lippincott-Raven, Philadelphia, 1996).

    Google Scholar 

  15. Goldfarb, L.G. et al. Creutzfeldt-Jacob disease associated with the PRNP codon 200Lys mutation: an analysis of 45 families. Eur. J. Epidemiol. 7, 477–486 (1991).

    Article  CAS  Google Scholar 

  16. Pocchiari, M. et al. A new point mutation of the prion protein gene in Creutzfeldt-jakob disease. Ann. Neural. 34, 802–807 (1993).

    Article  CAS  Google Scholar 

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  1. Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT, 59840, USA

    Bruce Chesebro

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  1. Bruce Chesebro
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Chesebro, B. Human TSE disease — viral or protein only?. Nat Med 3, 491–492 (1997). https://doi.org/10.1038/nm0597-491

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